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Ionis Pharmaceuticals - 34 Year Stock Price History | IONS

Historical daily share price chart and data for Ionis Pharmaceuticals since 1991 adjusted for splits and dividends. The latest closing stock price for Ionis Pharmaceuticals as of July 29, 2025 is 41.48.
  • The all-time high Ionis Pharmaceuticals stock closing price was 86.14 on April 08, 2019.
  • The Ionis Pharmaceuticals 52-week high stock price is 51.62, which is 24.4% above the current share price.
  • The Ionis Pharmaceuticals 52-week low stock price is 23.95, which is 42.3% below the current share price.
  • The average Ionis Pharmaceuticals stock price for the last 52 weeks is 36.85.
For more information on how our historical price data is adjusted see the Stock Price Adjustment Guide.
  
Ionis Pharmaceuticals Historical Annual Stock Price Data
Year Average Stock Price Year Open Year High Year Low Year Close Annual % Change
2025 34.0469 34.6900 43.5900 25.5100 41.4800 18.65%
2024 43.1008 52.8700 53.5500 33.7300 34.9600 -30.90%
2023 41.3095 37.5800 51.6300 33.5800 50.5900 33.94%
2022 38.7002 32.6000 48.6600 29.8800 37.7700 24.12%
2021 40.8556 56.7800 63.7800 25.6100 30.4300 -46.18%
2020 54.1692 60.8900 63.4000 41.6000 56.5400 -6.41%
2019 64.9707 53.7700 86.1400 52.9200 60.4100 11.75%
2018 48.2373 49.2500 59.5400 40.5300 54.0600 7.48%
2017 49.6931 47.3400 64.3900 37.9100 50.3000 5.16%
2016 35.8627 61.6800 61.6800 20.6200 47.8300 -22.77%
2015 59.1678 61.5700 77.0800 38.0400 61.9300 0.31%
2014 41.1384 39.8700 65.0900 22.9800 61.7400 54.97%
2013 25.5855 10.8200 41.6800 10.4900 39.8400 281.61%
2012 10.2666 7.2500 15.4100 7.0900 10.4400 44.80%
2011 8.2683 10.2900 10.3500 6.4700 7.2100 -28.75%
2010 9.6054 11.2700 11.7600 7.7800 10.1200 -8.91%
2009 14.2888 14.4700 18.7000 9.9400 11.1100 -21.65%
2008 14.7687 15.3800 19.0800 10.3700 14.1800 -9.97%
2007 12.1630 10.9300 17.7000 8.3700 15.7500 41.64%
2006 7.7520 5.2500 12.4900 5.1000 11.1200 112.21%
2005 4.4809 5.8000 5.8000 2.8000 5.2400 -11.19%
2004 6.3211 6.8100 9.5000 4.2700 5.9000 -9.23%
2003 5.5755 6.8400 8.0500 2.8000 6.5000 -1.37%
2002 11.4563 21.0500 21.2300 6.1900 6.5900 -70.30%
2001 14.2338 9.6250 26.6500 7.9375 22.1900 108.85%
2000 11.8580 5.8188 33.8125 5.8188 10.6250 71.64%
1999 10.7581 12.3329 15.6513 4.9832 6.1902 -48.11%
1998 11.6561 11.6413 14.4652 6.5122 11.9294 5.08%
1997 14.4116 16.5975 17.8653 10.6039 11.3531 -31.60%
1996 14.2324 12.1023 21.7842 9.6819 16.5975 37.14%
1995 9.0421 3.4578 13.8312 3.4578 12.1023 228.13%
1994 5.4607 6.5698 7.7224 3.1120 3.6883 -40.74%
1993 6.1197 8.9903 10.1429 5.0715 6.2241 -30.77%
1992 8.9899 12.2176 15.2144 4.8409 8.9903 -29.09%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $6.553B $0.705B
Ionis Pharmaceuticals discovers/develops RNA-targeted therapeutics using its proprietary antisense oligonucleotide technology. Its antisense medicines have been developed/are being developed to treat neurological, cardiovascular and specialty rare diseases.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $81.683B 31.42
Zoetis (ZTS) United States $67.115B 25.04
Daiichi Sankyo, - (DSNKY) Japan $46.355B 23.76
Takeda Pharmaceutical (TAK) Japan $45.533B 9.06
BeOne Medicines - (ONC) Cayman Islands $32.278B 0.00
Sandoz Group AG (SDZNY) Switzerland $26.052B 0.00
Summit Therapeutics (SMMT) United States $20.386B 0.00
Merck (MKKGY) Germany $16.931B 12.40
Shionogi (SGIOY) Japan $15.006B 15.03
United Therapeutics (UTHR) United States $13.448B 11.90
Neurocrine Biosciences (NBIX) United States $13.233B 45.33
Orion OYJ (ORINY) Finland $11.504B 27.72
IPSEN (IPSEY) France $10.846B 0.00
Stevanato Group S.p.A (STVN) Italy $7.865B 48.09
Corcept Therapeutics (CORT) United States $7.333B 59.61
Grifols, S.A (GRFS) Spain $6.937B 0.00
Madrigal Pharmaceuticals (MDGL) United States $6.531B 0.00
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $6.204B 0.00
Ono Pharmaceutical (OPHLF) Japan $5.214B 15.86
Soleno Therapeutics (SLNO) United States $4.296B 0.00
Hypermarcas (HYPMY) Brazil $2.971B 19.54
Crinetics Pharmaceuticals (CRNX) United States $2.837B 0.00
NewAmsterdam Pharma (NAMS) Netherlands $2.629B 0.00
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $2.561B 13.85
Catalyst Pharmaceuticals (CPRX) United States $2.537B 8.89
Centessa Pharmaceuticals (CNTA) United Kingdom $2.031B 0.00
Ocular Therapeutix (OCUL) United States $1.924B 0.00
Endo (NDOI) United States $1.813B 0.00
ARS Pharmaceuticals (SPRY) United States $1.802B 0.00
BioCryst Pharmaceuticals (BCRX) United States $1.728B 0.00
Evotec AG (EVO) Germany $1.513B 0.00
Guardian Pharmacy Services (GRDN) United States $1.313B 0.00
Harrow (HROW) United States $1.279B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.201B 24.03
Dyne Therapeutics (DYN) United States $1.058B 0.00
Avadel Pharmaceuticals (AVDL) Ireland $1.048B 0.00
Ardelyx (ARDX) United States $1.024B 0.00
Enliven Therapeutics (ELVN) United States $1.014B 0.00
Collegium Pharmaceutical (COLL) United States $1.008B 5.43
Akebia Therapeutics (AKBA) United States $0.943B 0.00
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Cronos Group (CRON) Canada $0.795B 0.00
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Amylyx Pharmaceuticals (AMLX) United States $0.712B 0.00
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Elite Pharmaceuticals (ELTP) United States $0.587B 0.00
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Tourmaline Bio (TRML) United States $0.581B 0.00
Theravance Biopharma (TBPH) United States $0.553B 0.00
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Oruka Therapeutics (ORKA) United States $0.525B 0.00
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Savara (SVRA) United States $0.460B 0.00
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Tonix Pharmaceuticals Holding (TNXP) United States $0.348B 0.00
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AleAnna (ANNA) United States $0.321B 0.00
Aldeyra Therapeutics (ALDX) United States $0.319B 0.00
Esperion Therapeutics (ESPR) United States $0.315B 0.00
Nanobiotix S.A (NBTX) France $0.313B 0.00
Nektar Therapeutics (NKTR) United States $0.293B 0.00
Heron Therapeutics (HRTX) United States $0.284B 0.00
Nature's Sunshine Products (NATR) United States $0.272B 24.97
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Larimar Therapeutics (LRMR) United States $0.233B 0.00
MediWound (MDWD) Israel $0.215B 0.00
4D Molecular Therapeutics (FDMT) United States $0.215B 0.00
Liminatus Pharma (LIMN) United States $0.210B 0.00
Lyell Immunopharma (LYEL) United States $0.203B 0.00
Galectin Therapeutics (GALT) United States $0.194B 0.00
Aclaris Therapeutics (ACRS) United States $0.182B 0.00
China SXT Pharmaceuticals (SXTC) China $0.181B 0.00
Journey Medical (DERM) United States $0.179B 0.00
Profound Medical (PROF) Canada $0.171B 0.00
Avita Medical (RCEL) United States $0.153B 0.00
Korro Bio (KRRO) United States $0.147B 0.00
Lexeo Therapeutics (LXEO) United States $0.141B 0.00
Inhibikase Therapeutics (IKT) United States $0.132B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.129B 0.00
Protara Therapeutics (TARA) United States $0.129B 0.00
Cardiol Therapeutics (CRDL) Canada $0.126B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.117B 0.00
Cassava Sciences (SAVA) United States $0.115B 0.00
Innate Pharma SA (IPHYF) France $0.110B 0.00
Fractyl Health (GUTS) United States $0.096B 0.00
Vivani Medical (VANI) United States $0.095B 0.00
Metagenomi (MGX) United States $0.094B 0.00
Achieve Life Sciences (ACHV) Canada $0.093B 0.00
VAXART, INC (VXRT) United States $0.093B 0.00
Nutriband (NTRB) United States $0.090B 0.00
Champions Oncology (CSBR) United States $0.087B 19.69
ESSA Pharma (EPIX) Canada $0.083B 0.00
Arch Biopartners (ACHFF) Canada $0.080B 0.00
Surrozen (SRZN) United States $0.080B 0.00
PMV Pharmaceuticals (PMVP) United States $0.078B 0.00
Dominari Holdings (DOMH) United States $0.077B 0.00
Context Therapeutics (CNTX) United States $0.076B 0.00
Pyxis Oncology (PYXS) United States $0.076B 0.00
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BioNxt Solutions (BNXTF) Canada $0.052B 0.00
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Klotho Neurosciences (KLTO) United States $0.052B 0.00
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Prelude Therapeutics (PRLD) United States $0.048B 0.00
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PolyPid (PYPD) Israel $0.037B 0.00
Plus Therapeutics (PSTV) United States $0.035B 0.00
Incannex Healthcare (IXHL) Australia $0.035B 0.00
Iterum Therapeutics (ITRM) Ireland $0.031B 0.00
Enlivex Therapeutics (ENLV) Israel $0.030B 0.00
Tempest Therapeutics (TPST) United States $0.030B 0.00
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Lipocine (LPCN) United States $0.018B 0.00
BioLineRx (BLRX) Israel $0.018B 0.00
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Citius Pharmaceuticals (CTXR) United States $0.016B 0.00
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Ernexa Therapeutics (ERNA) United States $0.014B 0.00
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BioVie (BIVI) United States $0.013B 0.00
Phio Pharmaceuticals (PHIO) United States $0.012B 0.00
TransCode Therapeutics (RNAZ) United States $0.012B 0.00
Ainos (AIMD) United States $0.011B 0.00
Lyra Therapeutics (LYRA) United States $0.010B 0.00
Biomerica (BMRA) United States $0.010B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.009B 0.00
Addex Therapeutics (ADXN) Switzerland $0.009B 0.00
Traws Pharma (TRAW) United States $0.009B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.009B 0.00
Talphera (TLPH) United States $0.009B 0.00
Mangoceuticals (MGRX) United States $0.009B 0.00
Aptorum Group (APM) United Kingdom $0.009B 0.00
NLS Pharmaceutics (NLSP) Switzerland $0.007B 0.00
Nuvilex (PMCB) United States $0.007B 0.00
Indaptus Therapeutics (INDP) United States $0.006B 0.00
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InMed Pharmaceuticals (INM) Canada $0.005B 0.00
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Quoin Pharmaceuticals (QNRX) United States $0.005B 0.00
Qualigen Therapeutics (QLGN) United States $0.005B 0.00
Clearmind Medicine (CMND) Canada $0.004B 0.00
SciSparc (SPRC) Israel $0.004B 0.00
Redhill Biopharma (RDHL) Israel $0.004B 0.00
SHINECO (SISI) China $0.003B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.003B 0.00
XORTX Therapeutics (XRTX) Canada $0.003B 0.00
PainReform (PRFX) Israel $0.003B 0.00
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Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.002B 0.00
Conduit Pharmaceuticals (CDT) United States $0.002B 0.00
Universe Pharmaceuticals INC (UPC) China $0.000B 0.00
Indivior (INDV) United States $0.000B 9.99
4D Pharma (LBPS) United Kingdom $0.000B 0.00
MEI Pharma (MEIP) United States $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00
Silence Therapeutics (SLN) United Kingdom $0.000B 0.00