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DURECT - 25 Year Stock Price History | DRRX

Historical daily share price chart and data for DURECT since 2000 adjusted for splits and dividends. The latest closing stock price for DURECT as of July 18, 2025 is 0.54.
  • The all-time high DURECT stock closing price was 158.12 on November 06, 2000.
  • The DURECT 52-week high stock price is 1.74, which is 222.2% above the current share price.
  • The DURECT 52-week low stock price is 0.48, which is 11.1% below the current share price.
  • The average DURECT stock price for the last 52 weeks is 0.96.
For more information on how our historical price data is adjusted see the Stock Price Adjustment Guide.
  
DURECT Historical Annual Stock Price Data
Year Average Stock Price Year Open Year High Year Low Year Close Annual % Change
2025 0.7116 0.7908 0.8700 0.4999 0.5353 -28.63%
2024 1.1587 0.5550 1.7800 0.5215 0.7500 27.12%
2023 3.8218 3.6000 8.7200 0.5020 0.5900 -82.95%
2022 5.6450 9.7500 9.7500 3.3900 3.4600 -64.91%
2021 16.0516 21.0000 28.7000 8.9560 9.8590 -52.37%
2020 20.0734 26.1500 28.5000 9.6780 20.7000 -45.53%
2019 11.8597 5.4020 38.0000 5.1200 38.0000 686.59%
2018 14.2259 9.2020 25.1000 4.8310 4.8310 -47.59%
2017 12.6894 13.4000 21.0000 7.7580 9.2180 -31.21%
2016 13.7067 20.4000 20.4000 10.1000 13.4000 -39.37%
2015 20.0206 8.3000 32.3000 8.3000 22.1000 180.03%
2014 14.1437 17.3000 22.2000 6.9570 7.8920 -54.38%
2013 12.3986 9.6000 17.5000 7.7080 17.3000 88.04%
2012 9.5235 12.0000 16.6000 6.9410 9.2000 -22.03%
2011 24.2069 35.9000 37.3000 11.5000 11.8000 -65.80%
2010 25.9768 25.6000 36.1500 19.5000 34.5000 39.68%
2009 24.4710 33.0000 33.9000 14.4000 24.7000 -27.14%
2008 46.5304 62.1000 64.3000 28.7000 33.9000 -47.28%
2007 47.9036 43.9000 69.0000 36.8000 64.3000 44.82%
2006 44.8070 50.7000 63.6000 27.6000 44.4000 -12.43%
2005 46.1877 31.2000 71.8000 26.4000 50.7000 54.57%
2004 26.7017 26.4000 42.3000 12.6000 32.8000 31.20%
2003 24.3274 21.2000 40.0000 11.2000 25.0000 23.76%
2002 62.5330 110.5000 116.0000 19.7000 20.2000 -82.57%
2001 88.3904 111.2500 140.0000 40.0000 115.9000 -3.42%
Sector Industry Market Cap Revenue
Medical Medical - Drug Manufacturing $0.016B $0.002B
Durect Corp. is pioneering the treatment of chronic diseases and conditions by developing and commercializing pharmaceutical systems to deliver the right drug to the right place in the right amount at the right time. Its pharmaceutical systems combine engineering innovations and delivery technology from the medical device and drug delivery industries with its proprietary pharmaceutical and biotechnology drug formulations.
Stock Name Country Market Cap PE Ratio
Chugai Pharmaceutical (CHGCY) Japan $76.846B 28.83
Zoetis (ZTS) United States $66.795B 24.92
Takeda Pharmaceutical (TAK) Japan $46.902B 9.33
Daiichi Sankyo, - (DSNKY) Japan $45.540B 23.34
BeOne Medicines - (ONC) Cayman Islands $31.822B 0.00
Sandoz Group AG (SDZNY) Switzerland $24.640B 0.00
Summit Therapeutics (SMMT) United States $20.520B 0.00
Merck (MKKGY) Germany $16.743B 12.27
Shionogi (SGIOY) Japan $14.360B 14.39
United Therapeutics (UTHR) United States $13.412B 11.86
Neurocrine Biosciences (NBIX) United States $13.272B 45.46
Orion OYJ (ORINY) Finland $10.973B 29.68
IPSEN (IPSEY) France $10.477B 0.00
Corcept Therapeutics (CORT) United States $7.752B 63.02
Madrigal Pharmaceuticals (MDGL) United States $7.743B 0.00
Stevanato Group S.p.A (STVN) Italy $7.719B 47.20
Grifols, S.A (GRFS) Spain $6.910B 0.00
Ionis Pharmaceuticals (IONS) United States $6.712B 0.00
Hikma Pharmaceuticals Plc (HKMPF) United Kingdom $6.153B 0.00
Ono Pharmaceutical (OPHLF) Japan $5.214B 15.86
Soleno Therapeutics (SLNO) United States $4.417B 0.00
Crinetics Pharmaceuticals (CRNX) United States $3.092B 0.00
Hypermarcas (HYPMY) Brazil $2.939B 19.33
Catalyst Pharmaceuticals (CPRX) United States $2.616B 9.17
AMNEAL PHARMACEUTICALS, INC (AMRX) United States $2.583B 13.97
NewAmsterdam Pharma (NAMS) Netherlands $2.468B 0.00
Centessa Pharmaceuticals (CNTA) United Kingdom $2.132B 0.00
BioCryst Pharmaceuticals (BCRX) United States $1.820B 0.00
Ocular Therapeutix (OCUL) United States $1.813B 0.00
ARS Pharmaceuticals (SPRY) United States $1.802B 0.00
Endo (NDOI) United States $1.622B 0.00
Evotec AG (EVO) Germany $1.506B 0.00
Harrow (HROW) United States $1.326B 0.00
Guardian Pharmacy Services (GRDN) United States $1.317B 0.00
Aurinia Pharmaceuticals Inc (AUPH) Canada $1.225B 24.51
Enliven Therapeutics (ELVN) United States $1.145B 0.00
Ardelyx (ARDX) United States $1.081B 0.00
Dyne Therapeutics (DYN) United States $1.068B 0.00
Avadel Pharmaceuticals (AVDL) Ireland $1.049B 0.00
Collegium Pharmaceutical (COLL) United States $1.037B 5.59
ProKidney (PROK) United States $1.030B 0.00
Akebia Therapeutics (AKBA) United States $1.019B 0.00
Verve Therapeutics (VERV) United States $0.976B 0.00
Xeris Biopharma Holdings (XERS) United States $0.818B 0.00
KalVista Pharmaceuticals (KALV) United States $0.800B 0.00
Cronos Group (CRON) Canada $0.791B 0.00
Amylyx Pharmaceuticals (AMLX) United States $0.738B 0.00
Zevra Therapeutics (ZVRA) United States $0.692B 0.00
Xencor (XNCR) United States $0.646B 0.00
Relay Therapeutics (RLAY) United States $0.626B 0.00
Elite Pharmaceuticals (ELTP) United States $0.609B 0.00
Theravance Biopharma (TBPH) United States $0.581B 0.00
Oruka Therapeutics (ORKA) United States $0.575B 0.00
USANA Health Sciences (USNA) United States $0.570B 12.40
Organogenesis (ORGO) United States $0.553B 0.00
Bioventus (BVS) United States $0.533B 13.52
Siga Technologies (SIGA) United States $0.479B 10.00
Tourmaline Bio (TRML) United States $0.478B 0.00
Aquestive Therapeutics (AQST) United States $0.434B 0.00
Savara (SVRA) United States $0.404B 0.00
Tonix Pharmaceuticals Holding (TNXP) United States $0.347B 0.00
Rigel Pharmaceuticals (RIGL) United States $0.338B 9.14
Nektar Therapeutics (NKTR) United States $0.331B 0.00
Altimmune (ALT) United States $0.328B 0.00
Heron Therapeutics (HRTX) United States $0.305B 0.00
AleAnna (ANNA) United States $0.301B 0.00
Aldeyra Therapeutics (ALDX) United States $0.301B 0.00
Nature's Sunshine Products (NATR) United States $0.271B 24.88
Nanobiotix S.A (NBTX) France $0.250B 0.00
Esperion Therapeutics (ESPR) United States $0.246B 0.00
OmniAb (OABI) United States $0.239B 0.00
MediWound (MDWD) Israel $0.217B 0.00
Larimar Therapeutics (LRMR) United States $0.213B 0.00
4D Molecular Therapeutics (FDMT) United States $0.202B 0.00
China SXT Pharmaceuticals (SXTC) China $0.196B 0.00
Galectin Therapeutics (GALT) United States $0.183B 0.00
Aclaris Therapeutics (ACRS) United States $0.172B 0.00
Profound Medical (PROF) Canada $0.171B 0.00
Journey Medical (DERM) United States $0.170B 0.00
Avita Medical (RCEL) United States $0.144B 0.00
Liminatus Pharma (LIMN) United States $0.142B 0.00
Lexeo Therapeutics (LXEO) United States $0.141B 0.00
Inhibikase Therapeutics (IKT) United States $0.141B 0.00
Lyell Immunopharma (LYEL) United States $0.141B 0.00
Korro Bio (KRRO) United States $0.130B 0.00
Ironwood Pharmaceuticals (IRWD) United States $0.128B 0.00
Protara Therapeutics (TARA) United States $0.121B 0.00
Champions Oncology (CSBR) United States $0.116B 19.00
Innate Pharma SA (IPHYF) France $0.110B 0.00
Corbus Pharmaceuticals Holdings (CRBP) United States $0.104B 0.00
Cassava Sciences (SAVA) United States $0.101B 0.00
Cardiol Therapeutics (CRDL) Canada $0.098B 0.00
Achieve Life Sciences (ACHV) Canada $0.095B 0.00
Vivani Medical (VANI) United States $0.094B 0.00
VAXART, INC (VXRT) United States $0.093B 0.00
Fractyl Health (GUTS) United States $0.088B 0.00
Nutriband (NTRB) United States $0.087B 0.00
Arch Biopartners (ACHFF) Canada $0.083B 0.00
ESSA Pharma (EPIX) Canada $0.083B 0.00
Dominari Holdings (DOMH) United States $0.082B 0.00
Context Therapeutics (CNTX) United States $0.082B 0.00
Rafael Holdings (RFL) United States $0.080B 0.00
Metagenomi (MGX) United States $0.080B 0.00
Verrica Pharmaceuticals (VRCA) United States $0.079B 0.00
Surrozen (SRZN) United States $0.073B 0.00
Pyxis Oncology (PYXS) United States $0.072B 0.00
PMV Pharmaceuticals (PMVP) United States $0.069B 0.00
Wellgistics Health (WGRX) United States $0.066B 0.00
Assertio Holdings (ASRT) United States $0.064B 0.00
Klotho Neurosciences (KLTO) United States $0.063B 0.00
Avalo Therapeutics (AVTX) United States $0.061B 0.00
Inotiv (NOTV) United States $0.061B 0.00
Unicycive Therapeutics (UNCY) United States $0.059B 0.00
Allergy Therapeutics (AGYTF) United Kingdom $0.059B 0.00
Jupiter Neurosciences (JUNS) United States $0.057B 0.00
Cumberland Pharmaceuticals (CPIX) United States $0.056B 41.22
ElectroCore (ECOR) United States $0.055B 0.00
NRx Pharmaceuticals (NRXP) United States $0.052B 0.00
Century Therapeutics (IPSC) United States $0.050B 0.00
Gain Therapeutics (GANX) United States $0.048B 0.00
Prelude Therapeutics (PRLD) United States $0.046B 0.00
Mural Oncology (MURA) Ireland $0.043B 0.00
Acrivon Therapeutics (ACRV) United States $0.041B 0.00
Iterum Therapeutics (ITRM) Ireland $0.039B 0.00
PolyPid (PYPD) Israel $0.039B 0.00
Telomir Pharmaceuticals (TELO) United States $0.036B 0.00
Karyopharm Therapeutics (KPTI) United States $0.035B 0.00
Vivos Therapeutics (VVOS) United States $0.034B 0.00
FibroGen (FGEN) United States $0.033B 0.00
SCYNEXIS (SCYX) United States $0.029B 0.00
Enlivex Therapeutics (ENLV) Israel $0.028B 0.00
Scienture Holdings (SCNX) United States $0.027B 0.00
Tempest Therapeutics (TPST) United States $0.025B 0.00
MARKER THERAPEUTICS, INC (MRKR) United States $0.022B 0.00
Natural Alternatives (NAII) United States $0.021B 0.00
BioLineRx (BLRX) Israel $0.020B 0.00
Relmada Therapeutics (RLMD) United States $0.020B 0.00
Plus Therapeutics (PSTV) United States $0.020B 0.00
Reviva Pharmaceuticals Holdings (RVPH) United States $0.019B 0.00
VYNE Therapeutics (VYNE) United States $0.018B 0.00
Citius Pharmaceuticals (CTXR) United States $0.017B 0.00
Lipocine (LPCN) United States $0.017B 0.00
Carisma Therapeutics (CARM) United States $0.017B 0.00
CASI Pharmaceuticals (CASI) China $0.016B 0.00
ProPhase Labs (PRPH) United States $0.016B 0.00
Ernexa Therapeutics (ERNA) United States $0.015B 0.00
BioVie (BIVI) United States $0.015B 0.00
Mannatech (MTEX) United States $0.015B 0.00
Minerva Neurosciences (NERV) United States $0.014B 2.43
TherapeuticsMD (TXMD) United States $0.013B 0.00
Cosmos Health (COSM) United States $0.013B 0.00
Ainos (AIMD) United States $0.012B 0.00
Phio Pharmaceuticals (PHIO) United States $0.012B 0.00
Lyra Therapeutics (LYRA) United States $0.011B 0.00
Incannex Healthcare (IXHL) Australia $0.011B 0.00
Aptorum Group (APM) United Kingdom $0.011B 0.00
Kiora Pharmaceuticals (KPRX) United States $0.010B 0.00
XTL Biopharmaceuticals (XTLB) Israel $0.010B 0.00
Addex Therapeutics (ADXN) Switzerland $0.009B 0.00
Traws Pharma (TRAW) United States $0.009B 0.00
Talphera (TLPH) United States $0.009B 0.00
Biomerica (BMRA) United States $0.009B 0.00
TransCode Therapeutics (RNAZ) United States $0.008B 0.00
Mangoceuticals (MGRX) United States $0.008B 0.00
NLS Pharmaceutics (NLSP) Switzerland $0.008B 0.00
Nuvilex (PMCB) United States $0.007B 0.00
Indaptus Therapeutics (INDP) United States $0.006B 0.00
Sonoma Pharmaceuticals (SNOA) United States $0.006B 0.00
Xenetic Biosciences (XBIO) United States $0.006B 0.00
Redhill Biopharma (RDHL) Israel $0.006B 0.00
Alaunos Therapeutics (TCRT) United States $0.005B 0.00
Qualigen Therapeutics (QLGN) United States $0.005B 0.00
InMed Pharmaceuticals (INM) Canada $0.005B 0.00
Quoin Pharmaceuticals (QNRX) United States $0.005B 0.00
Clearmind Medicine (CMND) Canada $0.004B 0.00
SciSparc (SPRC) Israel $0.004B 0.00
Galmed Pharmaceuticals (GLMD) Israel $0.004B 0.00
XORTX Therapeutics (XRTX) Canada $0.004B 0.00
SHINECO (SISI) China $0.004B 0.00
CERo Therapeutics Holdings (CERO) United States $0.003B 0.00
PainReform (PRFX) Israel $0.003B 0.00
Aditxt (ADTX) United States $0.003B 0.00
Heatwurx (PCSA) United States $0.003B 0.00
Jaguar Animal Health (JAGX) United States $0.002B 0.00
60 Degrees Pharmaceuticals (SXTP) United States $0.002B 0.00
Conduit Pharmaceuticals (CDT) United States $0.002B 0.00
Shuttle Pharmaceuticals Holdings (SHPH) United States $0.002B 0.00
TNF Pharmaceuticals (TNFA) United States $0.001B 0.00
Salarius Pharmaceuticals (SLRX) United States $0.001B 0.00
Universe Pharmaceuticals INC (UPC) China $0.000B 0.00
Indivior (INDV) United States $0.000B 9.45
4D Pharma (LBPS) United Kingdom $0.000B 0.00
MEI Pharma (MEIP) United States $0.000B 0.00
Patheon (PTHN) Netherlands $0.000B 0.00
RVL Pharmaceuticals (RVLP) United States $0.000B 0.00
Silence Therapeutics (SLN) United Kingdom $0.000B 0.00